uridine diphosphate造句

• The signalling effects of uridine triphosphate ( UTP ) and uridine diphosphate ( UDP ) are generally comparable to those of ATP.
• This mechanism proceeds with starting materials Uridine diphosphate N-acetylglucosamine, and a peptide chain with a reactive serine or threonine hydroxyl group.
• The homozygous Gunn rat, which lacks the enzyme uridine diphosphate glucuronyltransferase ( UDPGT ), is an animal model for the study of Crigler Najjar syndrome.
• UDP-glucuronic acid ( glucuronic acid linked via a glycosidic bond to uridine diphosphate ) is an intermediate in the process and is formed in the liver.
• This enzyme is located on the endoplasmic reticulum and catalyse the conjugation of a wide variety of lipophilic aglycon substrates with glucuronic acid, using uridine diphosphate glucuronic acid.
• Irinotecan is activated by hydrolysis to SN-38, an inhibitor of topoisomerase I . This is then inactivated by glucuronidation by uridine diphosphate glucoronosyltransferase 1A1 ( UGT1A1 ).
• A milder form of galactosemia, called Galactokinase deficiency, is caused a lack of the enzyme uridine diphosphate galactose-4-epimerase which breaks down a byproduct of galactose.
• A proposed mechanism supported by product inhibition patterns by UDP at saturating peptide conditions proceeds with starting materials Uridine diphosphate N-acetylglucosamine, and a peptide chain with a reactive serine or threonine hydroxyl group.
• Polysaccharides and glycans are made by the sequential addition of monosaccharides by glycosyltransferase from a reactive sugar-phosphate donor such as uridine diphosphate glucose ( UDP-glucose ) to an acceptor hydroxyl group on the growing polysaccharide.
• In leaves, UDP glucose pyrophosphorylase is a key part of the sucrose biosynthesis pathway, supplying Uridine diphosphate glucose to Sucrose-phosphate synthase which converts UDP-Glucose and D-fructose 6-phosphate into sucrose-6-phosphate.
• UGT-1A is a uridine diphosphate glucuronosyltransferase ( UDP-glucuronosyltransferase, UDPGT ), an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites.
• Piperine, an ingredient of pepper, promotes intestinal absorption by activation of the ?-glutamyltranspeptidase and inhibits the degradation of many compounds, by inhibiting different enzymes : aryl hydrocarbon hydroxylase ( AHH ), ethylmorphine N-demethylase, Uridine diphosphate ( UDP ) glucuronyltransferase ( UGT ), P-glycoprotein and CYP3A4.
• It decreases the glycolysis activity and allows carbohydrate metabolites to enter other pathways, like hexosamine pathway, Uridine diphosphate glucose glucose synthesis, glycerol synthesis and Pentose phosphate pathway or PPP . It helps in generating macromolecule precursors, that are necessary to support cell proliferation, and reducing equivalents such as NADPH . It has been observed in some studies that MYC promotes expression of PKM2 over PKM1 by modulating exon splicing.
• PGM3 deficiency is caused by a hypomorphic mutation in gene " PGM3 " ( OMIM # 172100 ) . " PGM3 " is a 29 kb gene with 14 exons, mapping to chromosome 6q14.1-q14.2 and encoding a 542 amino acid protein that serves as the crucial catalyst for the glycosylation pathway Protein PGM3 is required for the reversible conversion of GlcNAc-6-phosphate ( GlnNAc-6-P ) to GlnNAc-a-phosphate ( GlcNac-1-P ), a precursor step for the synthesis of uridine diphosphate N-acetylglucosamine ( UDP-GlcNAc ).
• Studies focusing on nerve tissue indicate that GPR17 is : "'a ) "'highly expressed in precursors to mature oligodendrocytes but not expressed in mature oligodendrocytes, suggesting that GPR17 must be down-regulated in order for precursor cells to proceed to terminal oligodendrocyte differentiation; "'b ) "'activated by uridine, Uridine diphosphate ( UDP ) and UDP-glucose to stimulate outward K + channels and the aforementioned maturation responses in oligodenrocyte precursor cells; "'c ) "'also activated by LTC4 and LTD4; "'d ) "'more highly expressed in central nervous system ( CNS ) tissues of animal models undergoing ischemia, Experimental autoimmune encephalomyelitis, and focal demyelination as well as in the CNS tissues of humans suffering brain damage due to ischemia, trauma, and multiple sclerosis; "'e ) "'expressed in injured neurons and associated with the rapid death and clearance of these neurons in a model of mouse spinal cord crush injury; "'f ) "'acts to reduce the extent of spinal cord injury in the latter model based on the increased extent of injury in GPR17-depleted mice; and "'g ) "'acts to reduce inflammation, elevate hippocampus neurogenesis, and improve learning and memory in a rat model of age-related cognitive impairment based on the effects of the GPR17 antagonist, montelukast, as well as of GPR17 depletion.